Anecdotally, it feels like Opus, Fable, and Sol "get distracted" when you use them for writing code. Great at reasoning and coordination but they will go off on a tangent and refactor half the code base. I only use them for reasoning (of course) and coordinating subagents.
Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO
I remember reading the Hazada paradox, where they found these Hadza tribe members who live an active life, walking miles, hunting, and doing all physical labour, have the same maintenance calories as a Western person.
So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members?
Pontzer’s research showed that while the Hadza were highly active, they actually demonstrated lower baselines of certain markers of metabolic and physiological stress over time compared to Western populations.
Don't quote me on this; I am paraphrasing things I remember from.
> Nonetheless, average daily energy expenditure of traditional Hadza foragers was no different than that of Westerners after controlling for body size. The metabolic cost of walking (kcal kg−1 m−1) and resting (kcal kg−1 s−1) were also similar among Hadza and Western groups. The similarity in metabolic rates across a broad range of cultures challenges current models of obesity suggesting that Western lifestyles lead to decreased energy expenditure.
> So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members?
P.S.: One theory I've seen is that the extra sedentary-spend is in the immune-system, which may have both beneficial and harmful effects, depending on whether it's doing useful work versus causing problems.
I've been posting about this including here for years now. I wrote a long post about it a while ago here and on Reddit. At time no one was talking about it, and actually my Reddit post was buried behind tons of others which was frustrating at the time given I had basically shared a partial cure.
Now if you search "reddit eds glp-1" or tirzepatide you'll see tons and tons of long threads of people all saying the same thing - it's the only thing that actually helps.
For me it was something of a miracle, I have two overlapping immune issues and it seems to just turn me into a much more normal, functional person. Including fixing my sleep.
Never was overweight beyond maybe ~15lbs btw when I started or took it, and the effects are 100% not because of just fasting or weight loss. I had tried keto and OMAD before, and been at healthy weight my whole life.
There's a definite auto-immune modulating mechanism and it's so strong it seems better than basically most first-class drugs. Even things like prednisone which are like nuclear weapons don't give me relief like Tirzepatide does.
Btw highly recommend Tirzepatide of the three GLP-1 drugs, for me at least it's by far the most effective and least side effects.
No, if that’s all it was then ME/CFS would be a cake walk and it isn’t. I have such a crazy restrictive diet and have had for a long time that one of my issues was being kicked out of doctor's offices for looking too healthy. The diet is necessary but not sufficient.
I'm in the same boat! I look very healthy, I'm young and most of my bloodwork is great but I have many autoimmune symptoms. I started on semaglutide 1 week ago and your comment brings me hope.
I started on an extremely small dose and worked up very slowly because I predicted and did in-fact have hyperactivity to it. I got gastroparisis and the associated huge amount of vomiting, couldn’t eat for the first few weeks. But slowly over the course of 3-6 months I was having few and fewer bad days. I take a bunch of other meds as well but this one is one of the most effective. I also do LDN, Amitryptiline, Modafinil, TUDCA, DIM, low dose of TRT and Ipamorelin/ModGRF. I eat the absolute minimum in sugar, one meal per day, and that is usually a large kale salad. The Modafinil / Amitryptiline is probably the most effective treatment I’ve tried, followed by the semaglutide, then the TRT/hGH peptides.
Super interesting - my friend has ME/CFS and/or Fibromyalgia and started GLP-1 but seemed to get only the negative side effects and not much benefit. Using Zepbound specifically.
Is the Modafinil used for alertness or a different off label purpose? I'm always interested in potential helpful interventions.
That reaction could very much be dose dependent. I think those in most need of the effect start out very hypersensitive to it and that reaction could easily obscure any benefits.
I use Modafinil and Amitryptiline as a rather unorthodox method for treating dysautonomia which seems to be an intrinsic precursor to ME/CFS, at least in my case where I have hEDS from a number of TNXB variants.
My overall theory is that a combination of anxiety disorders (genetic inability to ameliorate stress) pushes me into a Sympathetic state and keeps me there to the point that cytokines (or some undiscovered small molecule) are created by the immune system to knock me out of that state as a backup to other mechanisms that have stopped working. So I studied some psychopharmacology to design a drug combo that wouldn’t override the autonomic state so I could both work with my natural rhythms (using weaker ligands) and increase the magnitude of the swings so that I could spend enough time in the Parasympathetic state to obviate the need for the immune system backup. I take a lower dose of Modafinil (100mg started and stayed at this dose no apparent tolerance build) and am genetically very sensitive to caffeine so that and one coffee is enough to get me amped for the entire day, but I need amitryptiline to bring me back down to sleep (started as 25mg and many years later I’m at 125mg due to increasing tolerance). I do want to bring down my reliance on amitryptiline but I’m working crazy hours and figure I can wait to titrate down my dose later. I’ve been at this same dose for a year now so it’s at least not getting any worse).
Super interesting - friend is on a Adderall and Trazedone stack for energy/focus + sleep aid. Amitriptyline looks very interesting though I don't think they've tried that.
Thanks for the information, it's such a frustrating condition with a dearth of good information and research.
I did initially through some miracle, as I wasn’t overweight. But after that year was up I now do grey market. Finnrick does testing which seems like a decent way to source if you’re looking that way. Not affiliated though and haven’t done a lot of background research on them.
Apple TV is a little worrisome, surprised the A-series devices jumped so much. They're on older lines and have mostly been a way to recoup R&D for flagships. Theyre either subsidizing other products to soften the increase, or older process nodes are under serious demand suddenly.
Doesn't bode well for the industry. PlayStation and Xbox both switched to mostly-commodity hardware this gen and are years old, yet also facing the same price pressure apparently
The price increase may be factoring in the next Apple TV hardware revision, allowing that to be released without price being the dominant story around it.
Yeah, that seems to be the dominant theory, especially since the AppleTV hasn't been updated in a few years and is widely expected to be "due" for a new model within the next few months.
Is this true? I was under the impression that Apple signs long term deals with companies and the reason they didn't have a price hike for so long is because they were still getting parts are the former price
The trouble with long-term contracts is that they have an end date. Looking at my 5 year fixed mortgage which will end in just over a year, and it isn’t going to be pretty.
Apple doesn’t get a pass just because their contracts are many of orders of magnitude bigger.
As wonderful as long term deals are, if Apple signed a long term deal with a supplier who didn't secure their supply chain properly, said supplier is going to either:
1/ Force apple to eat a price hike. Failing that, they can:
2/ Terminate their relationship with apple
3/ Go bankrupt trying to sell $2 for $1 (which leads us back to point 1)
That has happened before with GT Advanced Technologies over iPhone screens. Apple frontloaded GTAT's Arizona facility buildout, but the contract had no obligation to buy and GTAT's yields were horrible, so Apple didn't pay the last installment of the loan and GTAT by contract couldn't sell to anyone else.
iPhone 6 launched without the sapphire screen and GTAT went bust.
Apple has a bit of a storied history of being the reason suppliers go bankrupt. Their contracts are usually one sided (who is going to tell Apple no and turn down that business?), and Apple does not like to be pushed around. They use multiple sourcing and pit their suppliers against one another and aren't above bullying.
its so much better though. android junk UI and TV OS are so bad I will happily pay the Apple TV price just to get the remote and not get a headache when I get home from work and want to watch TV. the product name is too poorly thought out though
Yeah, it's one of the products where you are clearly paying an Apple tax for the hardware, but OTOH it's also one of the products where it's clearest that the Apple tax is paying for software that's both good and consumer-friendly. It's not a hackable box, but if you want to just hand something to a non-technical person to use in their house, it's considerably better than the alternatives.
Right, this is the only reason I’d go for one if I ever had a reasonable opportunity. My Bravia is a nice TV, it’s solid in many respects, but the UI pushing ads and generally being unstable makes me not enjoy it.
It’s wild to think people can pay $2000 for the pleasure of seeing ads whenever they turn on their television (even in “apps only mod”), not to mention, I never have and will never enable the mic on the remote because fuck that, Google.
Tbh, Google TV may be one of my least favorite and most insidious Google products.
Agreed. But my argument was about the rising price of the hardware itself. If you install third-party apps on it, the software-side also becomes sort of moot? There are open-source alternatives, I’d never recommend Android for your set-top box.
Somewhere in one of the long videos, they mentioned that there were unique stickers on each of his items that he was selling on consignment. They had to have known which items were his.
It's due to fragmentation in implementations. The YAML spec is fairly large, and library authors understandably aren't excited at the prospect of dealing with all the minor details of less commonly used bits, like anchors.
You end up with YAML libraries being widely available and they all implement _most_ of the spec, but the portion not implemented varies. Plus there are minor variations in how people have read the spec, and even options _within_ the specification on how to handle parsing:
This isn't really a problem for projects like Kubernetes where most of the ecosystem uses the same library. On the other hand, OpenTelemetry is rolling out "declarative configuration" across all the supported languages. I work on OTel, and have avoided contributing in that area because I lack the patience to deal with the inconsistences - I don't hate YAML, but it can be frustrating.
AFAIK, the only 100% spec compliant implementation is libfyaml.
I see. I still wonder if the criticism is warranted in the particular context of Ansible playbooks.
First of all, who except Ansible (and ansible-lint) would even want to consume Ansible's YAML?
Regarding anchors: those are not idiomatic in Ansible at all, thanks to Ansible offering first-class support for object reuse on application level (e.g. variables and facts).
I wonder if TFA's pounding on YAML might be undeserved in this particular context.
I don't think YAML syntax is the core problem but understanding them as text files and not as serialized dicts/maps and lists.
Hell starts to open when people use string template languages to generate YAML files, such as in Helm charts. This is stupid because the templating language is not aware of the host language semantics. It is quite similar to the SQL or HTML injection problem we fought 20yrs ago and finally overcame with templated queries and auto-escaping.
Prompted the Jules preview to see what would happen. The implementation is pretty naive - there are much easier to read approaches I can think of. So not _awful_ considering the very short prompt I used.
If you use the product filter it only shows laptops that come pre-configured with 2TB of storage. If you choose a custom build you can configure the latest X1 Carbon with 32 GB RAM, 2 TB storage, and a 2.8k display.
If you choose the custom build route some even can ship with Fedora or Ubuntu, so presumably Linux support is reasonable.
Know some folks who used to work at Genscape. The whole business was selling live power generation data. They mostly accomplished it "hands-off" and without the permission of utilities.
If you had property adjacent to a power plant they would happily lease space to setup sensors.
Apparently there are tons of businesses like this gathering data that is mostly live and selling to hedge funds etc.
Everything is either in development or stable. There aren't statuses like alpha, beta, release candidate, etc. except for individual library releases. Metric clients will be marked as "development" until it goes "stable" [0]. Consequently it can be hard to determine the actual maturity level of any given implementation.
Tracing is very mature, with metric and logging implementations stable for a number of popular languages [1].
the "experimental" status was renamed "development"
Over 50% of the increased prices are from producers not just recouping their additional expenses, but also increasing profit margins.
Typically you would expect this to be an opportunity for competition, but generally speaking companies are suspiciously raising prices together. They've taken advantage of the COVID shortage and inflation narratives to squeeze consumers.
Corporate consolidation is one of the biggest and least talked about boogeymen of our current era, one which is set to get even worse under Trump's second term. The Biden admin barely, kind of, got anti-trust authorities somewhat working again, and that will be demolished on day 1 of Trump.
Bigger corpos means bigger donations to bigger candidates. The entire system runs on money and nobody's got money to put in like these supercorps. We live in Gerontocracy that is actively building a Corporatocracy to replace it after the Boomers die off entirely and no money will ever go to the working class again.
> If your change is no more durable than a single election, you didn't accomplish shit.
That is the way that the country works! The system is working as intended if a single government appointment can't unilaterally destroy monopolies in a single term.
What do you think inflation is? Demand shoots up, suppliers raise prices or run out, and it takes time for new capacity to be rewarded and created. There's no collusion here.
Inflation isn't just a fiscal (even though Biden failed on the fiscal side as well) or monetary phenomena, it's psychological - i.e. expectations about future prices.
Because the Biden administration was characteristically incompetent (Remember Treasury Secretary doing interviews saying that inflation was just a short-term blip and not persistent?) inflation started to get out of control. Once that happened, 30+ years of low inflation expectations went out the window. Market psychology changed, and because people now expected prices to rise, they weren't as resistant to individual price changes. This gave producers (along with legit covid supply side issues) breathing room to increase prices.
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